The development of tadalafil started in 1991 in England. It hit the market at roughly the same time as Viagra, but due to better marketing and slightly lower price, sildenafil managed to take the lead and topped the ratings for a long time.
One of the biggest downsides of Cialis compared to Viagra is its cost. Tadalafil is slightly more expensive than sildenafil. At the same time, the half-life time of tadalafil molecules is much longer compared to any other PDE5 inhibitor. This means that the drug can maintain its effect for longer periods of time. Field tests of the drug showed that the effect wears off only 48 hours after the intake. This is why you may have heard that Cialis is a “weekend drug”.
Pharmacodynamics of this medications are the same as that of sildenafil or any other PDE5 inhibitor. Generic Cialis starts working within 30-40 minutes and immediately fixes erectile dysfunction problems. In order to treat the problem, regular intakes of the medication in small dosages are highly recommended. Cialis also works well against PBH-related issues. The medication can help in treating urination problems that are often caused by this medical condition.
What are the main applications?
Tadalafil is your standard PDE5 inhibitor and can be used in a variety of ways.
There are three main medical applications of this drug:
- Erectile dysfunction related to blood pressure, blood vessel or other physiological issues. PDE5 inhibitors increase the production rate of nitrites in the organism and allows blood to flow easier filling the soft tissues of penis and causing strong erection. Note that sexual stimulation is still necessary to achieve the desired effect.
- Benign prostate hyperplasia that often causes urination problems and may be related to erectile dysfunction as well. Tadalafil is a good complementary drug in a treatment course of BPH. Please consult your doctor before starting using this drug together with other medications.
- Blood pressure related issues including pulmonary arterial hypertension. Due to its strong effect, the drug is also used by professional athletes to improve their ability to exercise.
What should I be aware of while using Tadalafil?
While PDE5 inhibitors are generally safe to use and do not require a specific routine, you should be aware of rare side effects and possible issues related to the medication. Over the course of field testing, the industry discovered additional health issues that can be caused by tadalafil. However, the connection between such cases and tadalafil is not yet established.
Temporary loss of hearing and sight. This side effect is now listed amongst other potential side effects. However, this happens rarely. Over the course of decades only a handful of men and women reported this issue.
Priapism. This is another relatively rare medical condition that may be caused by tadalafil. Priapism is a condition when the erection does not wear off after a significant amount of time. This issue may cause irreversible damage to penis and should be taken seriously. If the erection persists 3-4 hours, immediately start seeking for medical attention to prevent further damage of penis tissues.
Note that in rare cases patients may inherit retinitis pigmentosa, an eye condition. This indicates that the patient is highly sensitive to PDE5 inhibitors and should avoid using tadalafil altogether even in small dosages.
When is it dangerous to use?
You should avoid using this drug if you have following medical conditions:
Any disease related to heart or hear rhythm. Note that coronary artery related issues should also be a huge concern. This is due to the fact that tadalafil affects the blood pressure.
- Recovering from a recent heart attack that happened within 3 months.
- Repercussive strokes or heart failures.
- Blood pressure related health issues or angina.
- Being on dialysis.
- Any blood cell related disorder such as leukemia, anemia or myeloma. Also, hemophilia and other bleeding disorders.
- Various physical deformation of penis and its tissues.
- A stomach ulcer.
Having any of aforementioned health issues should be a huge concern. Please, avoid using tadalafil if you have any of conditions listed above. Note that PDE5 inhibitors heavily affect your blood pressure and may cause additional damage if taken when you have blood pressure related issues. Be careful and consult your doctor before using the drug.
What types of dosing of Cialis are there?
The medication itself is distributed in a variety of pills. You may find tablets of 2.5mg, 5mg, 10mg or 20mg. Depending on your needs, you can choose how much Cialis you need in order to improve your condition. There are two main methods of dosing and both of them should be considered one-dose-per-day treatment courses. Do not take more than 1 dose of Generic Cialis per day.
Daily Usage. You can take Cialis daily to treat both erectile dysfunction and benign prostate hyperplasia symptoms. Note that systematic intakes of tadalafil should be taken seriously.
Please, follow the instruction provided by the manufacturer:
- The recommended dose of tadalafil for daily usage is 2.5mg. The amount of medication can be adjusted by your doctor.
- Daily usage helps in treating BPH-related issues with urination and allows you to forget about your erectile dysfunction altogether. Men can have a successful intercourse anytime during the therapy involving Generic Cialis.
When Needed. Some men prefer to avoid systematic treatments and experience ED problems rarely. In such cases, using increased doses of the medication can be more productive.
Note that tadalafil has a very long half-life period and works for up to 48 hours after the intake:
- 20mg pill shows a strong effect within 30 minutes after the intake.
- The same pill will maintain its effect for at least 36 hours.
- Avoid increasing the dose and consult your doctor before starting to use Cialis irregularly.
How should I treat ED or BPH with Cialis?
Tadalafil is a perfect two-in-one medication for men with BPH and ED. Using Cialis daily will help you to mitigate all symptoms caused by benign prostate hyperplasia while effectively treating physiological problems affecting erectile function. 2.5mg of Generic Cialis is usually all it takes to treat both ED and BPH.
Note that tadalafil should not be taken together with other PDE5 inhibitors that you may use for treating ED and with some of medication that are used in BPH therapies. Please, consult your doctor before implementing Generic Cialis in your BPH and ED treatment routine.
What are the side effects and drug interactions?
Tadalafil, just like any other PDE5 inhibitor, should be taken with caution. While the compound has been studied excessively ever since its discovery in 1991, we still have a lot to learn about how our organism interacts with various medications. During clinical tests and over the course of decades of field testing, tadalafil was well studied.
Here is the list of side effects commonly caused by tadalafil based medications (Generic Cialis, Adcirca, etc.):
- Headaches;
- Digestion issues, most commonly indigestion and discomfort in abdomen;
- Muscle aches, common pains in back;
- Runny or, on the contrary, stuffy nose;
- Flushing.
These side effects are common indications that the medication works and rarely cause further discomfort. However, if these issues bother you, consider consulting with your doctor. All side effects usually wear off within 48 hours. Note that muscle pains and back pains are also common side effects and men generally start experiencing them within 24 hours after the intake of Generic Cialis. Again, these side effects go away quickly.
There are also extremely rare side effects that should also be taken seriously. While only a handful of patients ever experienced such consequences of Generic Cialis, it is better to be informed and well aware of such possibilities.
Here is the list of rare side effects:
- Temporary loss of hearing and/or sight. This issue has been reported several times. While it was not discovered during clinical trials, when the medication was released, a larger sample pool uncovered this possible side effect. Immediately consult with your doctor, if you have such symptoms.
- In rare cases, the erection may not go away after the intercourse. This is usually a completely normal thing, but a persistent erection for more than 2 hours should concern you. If your erection does not wear off within 4 hours, immediately seek for medical help in order to prevent significant irreversible damage to your penis tissues.
You should also be aware of negative drug interactions of Generic Cialis. As a PDE5 inhibitor that affects blood pressure and blood vessel system, Generic Cialis is a dangerous compound if used incorrectly.
Please, do not take Cialis together with medications listed below:
- Other tadalafil based medications. Increasing the daily dose of Cialis is dangerous and may harm your organism greatly. Be aware of other preparations that may contain tadalafil or other PDE5 inhibitors (sildenafil, vardenafil, etc.) For other medical applications, tadalafil is distributed under the brand of Adcirca.
- Usually prescribed for various types of chest pains, these medications are safe to use separately from Generic Cialis, but may cause problems related to blood pressure when used together. Also, this group includes various poppers and medications that contain nitrites (usually marketed as aphrodisiacs).
- Various medications prescribed for pulmonary arterial hypertension and/or chronic-thromboembolic hypertension. Medications that regulate your blood pressure.
- Alpha-blockers.
- Anti HIV and antifungal medications.
- Specific antibiotics. The list of such medications includes, but not limited to, telithromycin, erythromycin, clarithromycin.
How and where should I store Cialis?
Follow usual instruction for storing medications:
- Keep away from children;
- Do not leave the container opened;
- Keep it safe in a dark place.
It is usually a good idea to have a separate box for drugs and store it as far away from animals and children as possible. When transporting the medication, consider purchasing a compact container that will be used as a storage box for various medications. Make sure that such boxes can be properly sealed and protect the insides from moisture and sunlight.
What is inside a pill?
Generic Cialis and similar medications based on tadalafil also contain a variety of supplementary compunds that help the main ingredient to work more efficiently. Cialis usually contains a long list of inactive elements that are removed from your organism during the metabolism. However, you should be informed about the contains of the medication in order to know whether you are allergic to its specific ingredients.
Cialis usually contains:
- 5mg, 5mg, 10mg or 20mg of the active ingredient tadalafil;
- Croscarmellose sodium;
- Hydroxypropyl and/or microcrystalline cellulose;
- Talc;
- Iron oxide;
- Triacetin;
- Titanium dioxide;
- Magnesium sterate;
- Lactose monohydrate;
- Hypromellose;
- Sodium lauryl sulfate.
If you are allergic to any of the ingredients listed above, consider consulting with your doctor before starting a Cialis based therapy.
How does Cialis help against ED and BPH?
Cialis is primarily made of tadalafil. This is one of the most efficient PDE5 inhibitors in the market and it has various advantages compared to other PDE5 inhibitors. Tadalafil works similarly to other compunds from this group that includes vardenafil (Levitra), sildenafil (Viagra), Udenafil (Zydena), etc. PDE5 inhibitors increase the amount of cyclic GMP produced by the organism by forcing more NO (nitrite oxide) to be released immediately upon entering the organism. cGMP affects the arteries and soft penis tissues and allows the blood to flow easier. This makes erection stronger and easier to achieve. The blood fills the penis tissues quickly.
5 years ago, on October, 6, 2011, tadalafil was also approved by FDA to be used in treatment courses for benign prostate hyperplasia. While the whole mechanism is not yet fully studied, patients with BPH showed significant improvements while using Cialis. The medication helps with urination problems, normalizes the urine flow, and prevents frequent urination calls.
Both erectile dysfunction and benign prostate hyperplasia are treated via systematic therapy involving 2.5mg of tadalafil daily. This therapy reduces the symptoms of PBH and allows men to be ready for sexual intercourses all the time during the treatment course.
Are there alternative methods of BPH and ED treatment?
There are unconventional methods of treating erectile dysfunction with physiological origins. However, such methods have not yet proven effective enough. While some eastern medical methods show effect in some patients, this can be also a placebo effect. At the same time, various types of natural aphrodisiacs recommended everywhere do not work as well as described by pseudo-specialists.
Non-traditional methods of BPH treatment also doubtful. However, some complementary types of therapy may help. Usually, physicians recommend combining safe unconventional methods of treatment with massages, medications, and healthy lifestyle.
What is better, Tadalafil (Cialis) or Sildenafil (Viagra)?
When it comes to treating erectile dysfunction, both sildenafil and tadalafil are equally effective and provide strong erection when needed. However, due to its longer half-life period, tadalafil is not only more attractive as a “weekend drug”, but also works better as a part of a complex therapy that involves daily intakes of the medication.
While the effect of sildenafil wears off within 4-6 hours after the intake, tadalafil works for up to 48 hours and usually goes away after 36 hours. This makes tadalafil a better choice for those people who cannot plan their sexual intercourses and need passive treatment of their ED related issues.
Is Cialis (tadalafil) better than Viagra (sildenafil) for treating ED and BPH?
Yes. In short, tadalafil is a better option for those men who have both problems. Cialis helps in inhibiting various symptoms of BPH (most notably urination-related issues) and allows for a better long-term therapy while also being a very efficient “when it’s needed” type of drug.
Tadalafil affects prostate better due to being more effective in blocking PDE11 inhibitors that regulate prostate, liver, and other organism functions. Due to this fact, tadalafil is considered a bit more dangerous than sildenafil that mostly affects PDE6 inhibitor more (regulates eyes). Tadalafil much rarer affects eyesight and hearing, but much stronger affects prostate.
Should I purchase Brand Cialis or Generic Cialis? Price Comparison
The prices of branded Cialis vary greatly and depend on the distribution system. Comparing 20mg Cialis pills available in Canada, we can find that the lowest online price is roughly $11 per unit, while offline land-based pharmacies may charge you for over $25 per unit. This makes Cialis one of the most expensive medications in North America. Such a high price usually forces patients to search for cheaper alternatives or opt for purchasing a slightly cheaper branded Viagra.
However, Generic Cialis is much cheaper due to a variety of reasons:
- Produced offshore, such medications do not include expensive marketing costs in their price tag. Marketing is one of the biggest expenses of large pharmaceutical corporations.
- Cheaper distribution. Generic Cialis is distributed by independent companies that compete for their share of the market and try to provide their customers with interesting deals and regular offers. Free competition makes pricing fairer.
Here, at My Canadian Pharmacy, you can choose your 20mg pills for a price of $1.95 per item. There is a special offer that starts with $1.43 per item and provides you hefty bonuses! We are offering prices that are 3-5 times lower than in land-based pharmacies.